: Played by Lluís Homar , Rodrigo is depicted as a cunning schemer who ascends to the papacy through bribery and simony.

: Once installed as Pope, Rodrigo uses his children as pawns to expand Vatican territories and solidify his reign.

Often depicted in legends as a poisoner, the film takes a more sympathetic approach, portraying her as a victim of her father's political schemes through multiple arranged marriages.

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Ruling from 1492 to 1503, he is one of the most controversial popes in history. He was known for his unapologetic nepotism

Moreover, its failure taught producers a lesson: For a Renaissance drama to succeed, it needs either an auteur’s vision (Fontana’s gritty realism) or star-powered glamour (Jordan’s Irons). The 2006 version had neither—just a thoughtful script, a washed-out palette, and a release date that was five years too early.

Despite its short run, The Borgia has developed a loyal fan base over the years, and its influence can be seen in later television series and films about the Renaissance and historical dramas.