Juq-063 Direct

Note : The exact structure may vary slightly in different analytical reports because the “JUQ‑063” label has occasionally been used for closely related analogues. The description above reflects the most widely reported isomer.

| Study | Species | Duration | NOAEL* | Key Findings | |-------|---------|----------|--------|--------------| | (GLP) | Rat, dog | Single dose | 300 mg kg⁻¹ (rat), 150 mg kg⁻¹ (dog) | No mortality, mild transient sedation at top dose. | | 28‑day repeat‑dose (GLP) | Rat, dog | PO daily | 100 mg kg⁻¹ (rat), 50 mg kg⁻¹ (dog) | No clinical chemistry abnormalities; microscopic findings limited to mild reversible hepatocellular vacuolation at ≥150 mg kg⁻¹. | | Genotoxicity | — | Ames (5 strains) + mouse micronucleus | Negative | No mutagenic or clastogenic activity. | | Safety pharmacology | Rat (cardio), dog (CNS), rabbit (resp) | Single dose | No adverse effect | No QTc prolongation (ΔQTc < 5 ms), no motor impairment, no respiratory depression. | | Reproductive toxicity (Phase I) | Rat | 28‑day pre‑ and post‑natal | 30 mg kg⁻¹ | No teratogenicity or fertility impact. | JUQ-063